Fluorescent vasoactive intestinal peptide (VIP)
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United States of America Patent
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Nov 23, 2004
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app pub date -
Apr 2, 1999
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Jul 20, 1995
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Abstract
Light emitting compounds of the formula: ##STR1## wherein R.sub.1 is a light-emitting moiety and R.sub.2 is a VIP-based peptide, fragment, derivative or analog thereof, said peptide being linked at an amino acid position to (C--X), wherein (C--X) is selected from the group consisting of C.dbd.O, C.dbd.S, CH(OH), C.dbd.C.dbd.O, C.dbd.NH, CH.sub.2, CH(OR), CH(NR), CH(R), CR.sub.3 R.sub.4, and C(OR.sub.3)OR.sub.4 where R, R.sub.3, and R.sub.4 are alkyl moieties or substituted alkyl moieties, wherein said compound exhibits substantial biological activity in the presence of a receptor having affinity for VIP-based peptides.
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