Robust stain detection and quantification for histological specimens based on a physical model for stain absorption
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United States of America Patent
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Nov 16, 2004
Grant Date -
Oct 16, 2003
app pub date -
May 12, 2003
filing date -
May 29, 2001
priority date (Note) -
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Abstract
A physics based model of the absorption of light by histological stains used to measure the amount of one or more stains at locations within tissue is disclosed. The subsequent analysis results in several improvements in the detection of tissue on a slide, improvements to autofocus algorithms so focusing during image acquisition is confined to tissue, improvements to image segmentation and identification of tissued and its features, improvements to the identification of stain where multiple stains are used, and improvements to the quantification of the extent of staining. The invention relates to the application of these improvements to stain detection and quantification to provide for objective comparison between tissues and closer correlation between the presentations of such features and concurrent patterns of gene or protein expression.
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