Alkali metal salt of thiazolidine-2,4-dione derivative
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United States of America Patent
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Nov 16, 2004
Grant Date -
Jan 16, 2003
app pub date -
Jul 25, 2002
filing date -
Feb 1, 2000
priority date (Note) -
Expired
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Abstract
The invention provides alkali metal salt of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide and its hydrate. A method has been found, wherein, upon preparing KRP-297, the alkali metal salt of KRP-297 and its hydrate are formed in the reaction system and, after separation and purification, they are freed again from salt, thereby KRP-297 can be advantageously purified industrially for preparation.
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