Method of diagnosing and screening for male infertility through mutations in POLG
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United States of America Patent
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Nov 2, 2004
Grant Date -
N/A
app pub date -
Dec 4, 2001
filing date -
Feb 22, 1999
priority date (Note) -
Expired
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Abstract
The present invention relates to a novel diagnostic method for the detection of infertility in males. In particular, the present invention relates to a diagnostic method for detecting the presence or absence of a mutation or mutations in the POLG gene encoding mitochondrial DNA polmerase in a biological sample. The invention relates also to the use of a mutant POLG gene in the detection of infertility in males and in the screening of human populations for the presence of such mutation or mutations as a predictive test for male infertility. The invention also relates to the use of the POLG gene as an indicator of other pathological conditions associated with or related to male infertility, including those manifesting in women.
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