Methods of modulating immune coagulation
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United States of America Patent
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Oct 19, 2004
Grant Date -
May 29, 2003
app pub date -
Jul 12, 2001
filing date -
May 15, 1997
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Abstract
Methods for mediating immune coagulation using novel antibodies and compounds are described. A protein Fgl2 having direct prothrombinase activity has been identified. Inhibitors of Fgl2 are useful in preventing and treating diseases which require a reduction in immune coagulation including bacterial and viral infections, allograft and xenograft rejection, glomerulonephritis, cancer, a number of gastrointestinal diseases and fetal loss.
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