Process for the preparation of substituted octanoyl amides
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United States of America Patent
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Oct 5, 2004
Grant Date -
Sep 25, 2003
app pub date -
Jan 24, 2003
filing date -
Jul 25, 2000
priority date (Note) -
Expired
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Abstract
Compounds of formula (XII), are simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is reacted with an amine to form a carboxamide, the halogen is replaced with azide, if necessary after the introduction of a hydroxy protecting group, the resulting azide is converted to a lactone, the lactone is amidated and then the azide converted to the amine group, in order to obtain compounds of formula (I) or a salt thereof. ##STR1##
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