Modified factor VIII cDNA
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United States of America Patent
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Oct 5, 2004
Issued Date -
N/A
app pub date -
Jun 15, 2001
filing date -
Mar 17, 1999
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Expired
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Abstract
A modified Factor VIII cDNA is described in which the B-domain of the wild-type Factor VIII cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in one or more locatons of the Factor VIII cDNA. Such modified Factor VIII cDNA may be used for a higher yield production of Factor VIII in vitro as well as in a transfervector for gene therapy.
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