Succinate compounds, compositions and methods of use and preparation
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Sep 28, 2004
Grant Date -
Aug 22, 2002
app pub date -
Dec 13, 2000
filing date -
Dec 17, 1999
priority date (Note) -
Expired
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Abstract
Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.
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