Methods and compositions for enhancing diffusion of therapeutic agents through tissue
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United States of America Patent
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Sep 21, 2004
Grant Date -
Jun 6, 2002
app pub date -
Sep 12, 2001
filing date -
Dec 6, 2000
priority date (Note) -
Expired
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Abstract
The present invention provides methods and compositions for enhancing the diffusion of therapeutic agents through mammalian tissue. In one embodiment, invention provides methods and compositions useful for enhancing the diffusion of gene therapy vectors through a mammalian tissue of interest. The method comprises delivering the therapeutic agent and a permeabilizer to the tissue of interest. The method may further comprise inducing hyperthermia in the tissue. In one embodiment, a composition in accordance with the present invention comprises a gene therapy vector containing a polynucleotide and a tissue permeabilizer. A method of destroying tissue is also provided. In one embodiment of this aspect of the invention, the method includes delivering a high concentration of tissue permeabilizer to the tissue and may also include inducing hyperthermia in the tissue.
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