Process for the production of oxandrolone
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United States of America Patent
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Sep 7, 2004
Grant Date -
Jun 12, 2003
app pub date -
Dec 11, 2001
filing date -
Dec 11, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17.beta.-hydroxy-17.alpha.-methyl-5.alpha.-androst-1-en-3-one; (b) hydroxylating the 17.beta.-hydroxy-17.alpha.-methyl-5.alpha.-androst-1-en-3-one to form 1.alpha., 2.alpha., 17.beta.-trihydroxy-17.alpha.-methylandrostan-3-one; (c) cleaving the 1.alpha., 2.alpha., 17.beta.-trihydroxy-17.alpha.-methylandrostan-3-one to form 17.beta.-hydroxy-17.alpha.-methyl-1-oxo-1,2,-seco-A-nor-5.alpha.-androstan-2-oic acid; and (d) reducing the 17.beta.-hydroxy-17.alpha.-methyl-1-oxo-1,2,-seco-A-nor-5.alpha.-androstan-2-oic acid to form oxandrolone.
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