Gene transfer methods
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United States of America Patent
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Sep 7, 2004
Grant Date -
N/A
app pub date -
Jan 9, 2001
filing date -
Jul 1, 1998
priority date (Note) -
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Abstract
Improved methods for transferring a gene into target cells by using a retrovirus, wherein the gene transfer efficiency is improved and the target cells are efficiently transformed by binding the retrovirus to a functional substance which is immobilized on as carrier and having an activity of binding to retroviruses followed by washing; using an antibody capable of specifically recognizing cells, laminin or mannose-rich type sugar chain as a substance having an activity of binding to the target cells; pre-treating the target cells so as to inactivate transferrin receptor, or introducing a new functional group into the functional substance.
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