Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology
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United States of America Patent
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Sep 7, 2004
Grant Date -
N/A
app pub date -
Jun 1, 2000
filing date -
Jun 1, 1999
priority date (Note) -
Expired
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Abstract
There is provided an assay method for determining the effect of an agent on Alzheimer's Disease pathology by treating microglial cells with A.beta. peptides, adding CD40 ligand to the microglial cells, adding a therapeutic agent to the microglial cells, and measuring Alzheimer's Disease pathology. Also provided is a method of determining therapeutic effectiveness of an agent for Alzheimer's Disease by measuring the inhibition of CD40-CD40L binding in the presence of the agent. An assay for determining the effect of an agent on Alzheimer's Disease pathology having A.beta. peptides for adding to microglial cells, CD40 ligand for being added to the microglial cells, a therapeutic agent being added to the microglial cells and a measuring device for reassuring Alzheimer's Disease pathology is also provided.
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