MMP inhibitors
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Aug 31, 2004
Grant Date -
Oct 9, 2003
app pub date -
Jan 16, 2003
filing date -
Jan 18, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Novel compounds according to formula I ##STR1## n is 0, 1, 2 or 3; X represents hydroxamic acid (CONHOH), carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group; R2, R10 and R11 independently represent hydrogen or (C.sub.1-8)alkyl, (C.sub.2-6)alkenyl, (C.sub.3-8)cycloalkyl, aryl(C.sub.0-6)alkyl or heteroaryl(C.sub.0-6)alkyl, all of which may optionally be substituted; R3 and R4 independently represent hydrogen, hydroxy or alkoxy; provided that if A, A', Z and R5 are all bonds, and s and t are both 0 (zero), then R6 is different from hydrogen, and that at least one of R3, R4, R10 and R11 is different from hydrogen; or a salt, hydrate or solvate thereof; pharmaceutical compositions comprising said compound; therapeutical methods comprising administering said compounds; and the use of said compounds in the manufacture of medicaments.
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