Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood
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United States of America Patent
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Aug 24, 2004
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N/A
app pub date -
Jun 22, 2000
filing date -
Jun 22, 1999
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Expired
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Abstract
The present invention is a complex of a polynucleotide having a property of specifically binding to a target protein together with a protein that stabilizes the polynucleotide from degradation and from clearance from the circulation in vivo. Methods for diagnostic imaging and therapeutic uses of the complex are disclosed.
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