Modified factor VIII cDNA and its use for the production of factor VIII
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United States of America Patent
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Aug 24, 2004
Grant Date -
Dec 5, 2002
app pub date -
Feb 8, 2002
filing date -
Feb 9, 2001
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Abstract
A modified Factor VIII cDNA is disclosed wherein the B-domain of the wild type factor cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in two locations of the Factor VIII cDNA and as a promoter a cDNA is used which is suitable for the expression in hematopoietic cell lines and specifically in platelets.
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