Adjuvant for a vaccine composition
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United States of America Patent
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Aug 24, 2004
Grant Date -
N/A
app pub date -
Sep 9, 1997
filing date -
Nov 14, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An amphipathic compound including a sterol-derived lipophilic grouping bound to a cationic grouping for use as an adjuvant in the delivery of a vaccine composition. In a particular embodiment, the lipophilic grouping is a cholesterol derivative and the cationic grouping is a quaternary ammonium or a protonatable amine. A vaccine composition including one or more antigens with at least one amphipathic compound having a sterol-derived lipophilic grouping bound to a cationic grouping, is also disclosed.
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