Pox virus comprising DNA sequences encoding CEA and B7 antigen
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United States of America Patent
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Aug 24, 2004
Issued Date -
N/A
app pub date -
Sep 15, 2000
filing date -
Mar 8, 1989
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Expired
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Abstract
Attenutated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of: human tumor necrosis factor; nuclear phosphoprotein p53, wiltype or mutant; human melanoma-associated antigen; IL-2; IFN.gamma.; IL-4; GMCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.
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