Method and structure for inhibiting activity of serine elastases
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United States of America Patent
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Aug 17, 2004
Grant Date -
Jul 17, 2003
app pub date -
Dec 23, 2002
filing date -
Jun 17, 1999
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Expired
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Abstract
Therefore, it is critical that the roles these enzymes play in biological processes outside of extracellular matrix degradation or remodeling be understood in order to assess their potential as targets for therapeutic intervention, and to design safe, conveniently produced, orally active inhibitors. Elastase inhibitors can differ with respect to their ability to inhibit different elastases. As a result, the spectrum of elastases inhibited by a specific drug candidate as well as the spectrum of activities these enzymes have with respect to proteins other than elastin are properties to consider in evaluating the drug candidates.
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