Process for microencapsulation of water soluble substances

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United States of America Patent

PATENT NO 6777002
SERIAL NO

09958806

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Abstract

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The present invention relates to a process for the preparation of microparticles, with an extremely high encapsulation rate, comprising a water-soluble substance in a biodegradable polymer, said water-soluble substance and said biodegradable polymer being first incorporated in an organic liquid phase comprising at least one organic non-water miscible solvent. The organic phase is poured into an aqueous liquid phase having a volume which is sufficient to dissolve said organic solvent, said aqueous phase containing a surfactant, the resulting organic-aqueous phase being homogenised in order to perform in one single step the microparticle formation and the organic solvent removal. The thus obtained microparticles show surprisingly good agent retention qualities.

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Patent Owner(s)

Patent OwnerAddress
DEBIO RECHERCHE PHARMACEUTIQUE S ASWITZERLAND ZUG ZUG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Orsolini, Piero Martigny, CH 18 834
Vuaridel, Evelyne Nyon, CH 2 9

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