Use of combretastatin A4 and its prodrugs as an immune enhancing therapy
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United States of America Patent
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Aug 10, 2004
Grant Date -
Oct 31, 2002
app pub date -
Dec 26, 2001
filing date -
Dec 26, 2000
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Abstract
A method of treating immune suppression in a warm-blooded animal bearing a tumor, by administering to the animal an amount of combretastatin A4 and/or a prodrug thereof effective to enhance immune responsiveness without causing vascular destruction. Immunotherapy treatment to inhibit or kill tumor cells includes administering to the animal an immune-response-stimulating agent such as a vaccine of tumor cells genetically modified to produce an immune-response-enhancing cytokine while counteracting tumor-induced immune suppression in the animal by administering combretastatin A4 and/or a prodrug thereof.
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