Adenovirus E1B shuttle vectors
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United States of America Patent
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Jul 20, 2004
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N/A
app pub date -
Dec 27, 1999
filing date -
Jan 28, 1999
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Expired
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Abstract
Provided are replication competent, recombinant adenovirus vectors containing mutations in the E1B region which permit the easy deletion of a gene or genes therein, and optionally the substitution therefore of a heterologous gene that substantially exhibits the temporal expression pattern of the E1b region gene(s) deleted. Such vectors have applications for the treatment of disease, and preferably for the treatment of neoplastic disease.
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