Membrane derived caspase-3, compositions comprising the same and methods of use therefor
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United States of America Patent
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Jul 13, 2004
Grant Date -
Oct 24, 2002
app pub date -
Mar 20, 2002
filing date -
Nov 20, 2000
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Abstract
Provided are isolated nucleic acids encoding a novel membrane derived caspase-3 and polypeptides expressed therefrom. In one embodiment, the nucleic acid expression vectors that produce membrane derived caspase-3 polypeptide may be introduced into host cells as a gene delivery vehicle. In other embodiments, methods are provided for treating pathological disorders caused by altered apoptosis, such as autoimmune disease, cancer, viral infections, and bacterial infections. Another aspect of the invention is the use of the isolated nucleic acid encoding membrane derived caspase-3 and polypeptides expressed therefrom as a means for promoting or inhibiting programmed cell death.
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