Pharmaceutical kit comprising midodrine as active drug substance
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United States of America Patent
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Jul 13, 2004
Grant Date -
Dec 19, 2002
app pub date -
Mar 29, 2001
filing date -
Mar 31, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides a novel pharmaceutical kit comprising a controlled release pharmaceutical compositions for oral use containing midodrine and/or its active metabolite desglymidodrine. The controlled release composition is designed to release midodrine and/or desglymidodrine after oral intake in a manner which enables absorption to take place in the gastrointestinal tract so that a relatively fast peak plasma concentration of the active metabolite desglymidodrine is obtained, followed by a prolonged and relatively constant plasma concentration of desglymidodrine. The invention also provides a method for treating orthostatic hypotension and/or urinary incontinence, the method comprising administration to a patient in need thereof of an effective amount of midodrine and/or desglymidodrine in a kit.
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