Odc allelic analysis method for assessing carcinogenic susceptibility
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United States of America Patent
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Jun 22, 2004
Grant Date -
Jun 27, 2002
app pub date -
Jul 24, 2001
filing date -
Mar 1, 1999
priority date (Note) -
Expired
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Abstract
The invention includes kits and methods for assessing the susceptibility of a mammal such as a human for carcinogenesis. The methods comprise determining whether the mammal comprises a certain allele of the mammal's odc gene. The methods include use of a probe which binds specifically with a portion of one allele of the odc gene and which comprises a fluorescent label and a fluorescence quencher. The methods also include use of such a probe and a polymerase enzyme for amplifying a portion of the odc gene, the polymerase having exonuclease activity whereby the probe can be nucleolytically degraded.
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