Pharmaceutical composition
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United States of America Patent
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Jun 22, 2004
Grant Date -
N/A
app pub date -
Oct 22, 2001
filing date -
Apr 23, 1999
priority date (Note) -
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Abstract
A pharmaceutical composition for dermal use, wherein the composition has a first pharmacologically active component A consisting of at least one vitamin D or vitamin D analogue, and a second pharmacologically active component B consisting of at least one corticosteroid, wherein the difference between the maximum stability pH of said first component A and the maximum stability pH of said second component B is at least 1. The composition can also have at least one solvent component C, where component C is compounds of the general formula R.sup.3 (OCH.sub.2 C(R.sup.1)H).sub.x OR.sup.2 (I), wherein x is in the range of 2-60, R.sup.1 in each of the x units independently is H or CH.sub.3, R.sup.2 is straight chain or branched C.sub.1-20 alkyl or benzoyl, and R.sup.3 is H or phenylcarbonyloxy; di-(straight or branched)-C.sub.4-10 alkyl esters of C.sub.4 -C.sub.8 dicarboxylic acids; straight or branched C.sub.12-18 -alkyl benzoates; straight or branched C.sub.2-4 -alkyl esters of straight or branched C.sub.10-18 -alkanoic or -alkenoic acids; propylenglycol diesters with C.sub.8-14 -alkanoic acids; and branched primary C.sub.18-24 alkanols.
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