Detection of biological molecules using boronate-based chemical amplification and optical sensors
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United States of America Patent
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Jun 15, 2004
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app pub date -
Dec 14, 1999
filing date -
Nov 21, 1996
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Abstract
Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
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