Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion

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United States of America Patent

PATENT NO 6747148
APP PUB NO 20020065271A1
SERIAL NO

09972190

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Abstract

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Sulfonamide derivatives, their physiologically tolerable salts and their prodrugs according to the present invention are vitronectin receptor antagonists and inhibitors of cell adhesion, as well as inhibit bone resorption by osteoclasts. These derivatives, salts and prodrugs are pharmaceutically active compounds useful in the therapy and prophylaxis of diseases which are caused at least partially by an undesired extent of bone resorption, for example of osteoporosis. Processes for the preparation of the sulfonamide derivatives according to the present invention, the use of these derivatives as pharmaceutically active ingredients, and pharmaceutical preparations comprising these derivatives also are disclosed.

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Patent Owner(s)

Patent OwnerAddress
HOECHST MARION ROUSSEL DEUTSCHLAND GMBHINDUSTRIEPARK HOECHST D-65926 FRANKFURT AM MAIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bodary, Sarah Catherine San Bruno, CA 10 116
Carniato, Denis Marcoussis, FR 56 250
Cuthbertson, Robert Andrew Victoria, AU 5 42
Gadek, Thomas R Oakland, CA 36 1667
Gourvest, Jean-Francois Souilly, FR 38 225
Knolle, Jochen Kriftel, DE 68 504
McDowell, Robert San Francisco, CA 68 674
Peyman, Anuschirwan Kelkheim, DE 48 770
Scheunemann, Karlheinz Liederbach, DE 6 32
Will, David William Schwalbach, DE 45 498

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