Methods for the identification of inhibitors of histidinol-phosphate as antibiotics
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United States of America Patent
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May 25, 2004
Grant Date -
Aug 7, 2003
app pub date -
Dec 6, 2001
filing date -
Dec 6, 2001
priority date (Note) -
Expired
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Abstract
The present inventors have discovered that histidinol-phosphatase is essential for fungal pathogenicity. Specifically, the inhibition of histidinol-phosphatase gene expression in fungi results in small, non-sporulating lesions and reduced pathogenicity. Thus, histidinol-phosphatase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit histidinol-phosphatase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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