Process for preparation of 4,5-epoxymorphinan-6-oxyglucuronides
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United States of America Patent
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May 18, 2004
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N/A
app pub date -
May 18, 2001
filing date -
May 13, 1998
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Expired
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Abstract
Conjugation of 4,5-Epoxymorphinan-6-ols with Bromoglucuronides in the presence of Zinc containing compounds as activator under conditions capable of forming 4,5-Epoxymorphinan-6-oxyglucuronides is disclosed. This novel approach provides an efficient method for preparation of both anomers of 4,5-Epoxymorphinan-6-oxyglucuronides. The deprotected end products are useful as analgesic agents.
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