Mixed buffer system for stabilizing polypeptide formulations
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United States of America Patent
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May 11, 2004
Grant Date -
Oct 18, 2001
app pub date -
Dec 8, 2000
filing date -
Jan 24, 2000
priority date (Note) -
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Abstract
The present invention is a pharmaceutical composition for polypeptide which are not stably soluble. A preferred polypeptide is monomeric insulin and a preferred formulation consists of a TRIS-phosphate combination buffer, zinc; a phenolic preservative and an isotonicity agent such as glycerol.
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