Methods for the identification of inhibitors of 3-isopropylmalate dehydratase as antibiotics
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United States of America Patent
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May 11, 2004
Grant Date -
Jul 31, 2003
app pub date -
Dec 6, 2001
filing date -
Dec 6, 2001
priority date (Note) -
Expired
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Abstract
The present inventors have discovered that 3-Isopropylmalate dehydratase is essential for fungal pathogenicity. Specifically, the inhibition of 3-Isopropylmalate dehydratase gene expression in fungi results in no signs of successful infection or lesions. Thus, 3-Isopropylmalate dehydratase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit 3-Isopropylmalate dehydratase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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