Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives
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United States of America Patent
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Apr 27, 2004
Grant Date -
Dec 5, 2002
app pub date -
Jul 23, 2002
filing date -
Aug 28, 1997
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Expired
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Abstract
Disclosed are the compounds of formula I ##STR1## wherein R is methyl or ethyl; R.sub.1 is chloro or fluoro; R.sub.2 is hydrogen or fluoro; R.sub.3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R.sub.4 is hydrogen or fluoro; and R.sub.5 is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.
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