Identification of target structures E.G. in vivo selection method for a phage library
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United States of America Patent
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Apr 27, 2004
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N/A
app pub date -
Jul 30, 1999
filing date -
Jan 31, 1997
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Abstract
The invention relates to a selection method and the products identified using the selection method which includes the steps of identifying one or more binding structures to a target structure using one or more libraries. The method includes the steps of reacting a first library with the displayed target structure to bind some of the binding structures to the displayed target structure, separating the displayed target structure and bound binding structures from unbound binding structures, and recovering bound or unbound binding structures. The bound or unbound binding structures can be amplified to create enriched libraries of binding structures. Binding structures thus identified are directed to target structures which are displayed in vivo and/or in situ.
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