Sustained release heterodisperse hydrogel systems for insoluble drugs
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United States of America Patent
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Apr 27, 2004
Issued Date -
N/A
app pub date -
Sep 5, 2000
filing date -
Sep 9, 1993
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Expired
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Abstract
A sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional cationic cross-linking agent, and a medicament having moderate to poor solubility is disclosed. In certain embodiments, the sustained release excipient is granulated with a solution or suspension of a hydrophobic polymer in an amount effective to slow the hydration of the gelling agent when the formulation is exposed to an environmental fluid. In another embodiment, the tablet is coated with a hydrophobic polymer.
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