Propanoic acid derivatives that inhibit the binding of integrins to their receptors
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United States of America Patent
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Apr 20, 2004
Grant Date -
Oct 23, 2003
app pub date -
Oct 9, 2001
filing date -
May 7, 1999
priority date (Note) -
Expired
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Abstract
A compound of the structure ##STR1## A method for the inhibition of the binding of .alpha..sub.4.beta..sub.1 integrin to its receptors, for example VCAM-1(vascular cell adhesion molecule-1) and fibronectin; pharmaceutically active compositions comprising these compounds; and the use of these compounds for the control or prevention of diseases states in which .alpha..sub.4.beta..sub.1 is involved are also disclosed.
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