Method for producing and screening mass-coded combinatorial libraries for drug discovery and target validation
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United States of America Patent
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Apr 13, 2004
Grant Date -
Dec 5, 2002
app pub date -
Apr 26, 2002
filing date -
Jan 5, 1998
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Abstract
The present invention provides an apparatus for producing a mass-coded combinatorial library comprising a set of compounds having the general formula X(Y).sub.n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1. The apparatus comprises a digital processor assembly for selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 50 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. Methods of use of the mass-coded combinatorial library produced by this apparatus are also disclosed.
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