Antioxidant nitroxides and nitrones as therapeutic agents
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United States of America Patent
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Apr 6, 2004
Grant Date -
Mar 6, 2003
app pub date -
Apr 2, 2002
filing date -
Apr 2, 2001
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Expired
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Abstract
The invention provides novel adamantane compounds having one of the following formulas: ##STR1## wherein: R.sub.1 and R.sub.3 are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different; R.sub.2 is H, NH.sub.2, alkyl, OH, COOH, amino, amide, or carbamate; R.sub.4 -R.sub.8 are H, OH, NH.sub.2, alkyl, OH, COOH, ester, amino, amide, or alkyloxy, and can be the same or different; R.sub.9 -R.sub.14 are H, alkyl, or phenyl, and can be the same or different; and wherein when any of R.sub.1 -R.sub.8 is amino, the compounds are the free bases and their acid addition salts. The present invention also relates to compositions and methods for treating and/or preventing neurological and inflammatory disorders in a patient by administering a therapeutically effective amount of the compounds of formula (I), (II) or (III) and a pharmaceutically acceptable carrier.
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