Nucleic acids encoding a chloride channel protein
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United States of America Patent
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Apr 6, 2004
Grant Date -
Apr 24, 2003
app pub date -
Oct 16, 2002
filing date -
Mar 3, 1998
priority date (Note) -
Expired
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Abstract
A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.
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