Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens
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United States of America Patent
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Mar 30, 2004
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app pub date -
Nov 29, 2000
filing date -
Jun 20, 1998
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Abstract
The present invention is directed to novel artificial T helper cell epitopes (Th epitopes) designed to provide optimum immunogenicity when used in peptide immunogens comprising B cell epitopes or peptide haptens, a target antigenic site of a target antigen for eliciting antibodies thereto. The artificial Th epitopes are covalently linked to the target antigenic site and and optionally an immunostimulatory sequence to provide effective and safe peptide immunogens.
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