Bioactivated diagnostic imaging contrast agents
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United States of America Patent
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Mar 23, 2004
Grant Date -
Mar 21, 2002
app pub date -
Sep 14, 2001
filing date -
Apr 1, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bloactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
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