Dicarboxylato diammine platinum derivatives and compositions comprising them as anti-tumor agents
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United States of America Patent
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Mar 2, 2004
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N/A
app pub date -
Aug 12, 2002
filing date -
Mar 3, 2000
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Abstract
The present invention relates to an antitumor derivative of double dicarboxylic acid diaminoplatin complex of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 have the meanings defined in the specification, also relates to a process for preparation thereof, to an antitumor pharmaceutical composition containing the same, and further to application of the derivative in making antitumor pharmaceutics. The composition is a new generation of safe and effective antitumor drug, which has advantages such as low toxicity, broad antitumor spectrum, high antitumor activity, good solubility in water and fine stability in aqueous solution, selective killing of cancer cells without damaging normal cells, etc.
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