Injectable implants for tissue augmentation and restoration
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United States of America Patent
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Mar 2, 2004
Grant Date -
Mar 28, 2002
app pub date -
Apr 18, 2001
filing date -
Feb 27, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method for tissue augmentation in a mammal is provided comprising injecting a polymer at a tissue site in need of augmentation and having a tissue temperature, the polymer comprising repeating peptide monomeric units selected from the group consisting of nonapeptide, pentapeptide and tetrapeptide monomeric units, wherein the monomeric units form a series of .beta.-turns separated by dynamic bridging segments suspended between the .beta.-turns, wherein the polymer has an inverse temperature transition T.sub.t less than the tissue temperature, and wherein the polymer is injected as a water solution at coacervate concentration in the substantial absence of additional water. A kit containing the injectable bioelastic polymer and a syringe is also provided.
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