Process for treating lameness by administration of a bisphosphonic acid derivative
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United States of America Patent
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Feb 24, 2004
Grant Date -
Feb 13, 2003
app pub date -
Sep 5, 2002
filing date -
Oct 2, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to a process for treating lameness with an osseous, articular or osteoarticular component, comprising the administration, to a human or to an animal not suffering from arthritis or from fractures, of an effective amount of a bisphosphonic acid derivative of formula: ##STR1## in which: R.sub.1 represents a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono(C.sub.1 -C.sub.4)alkylamino or a di(C.sub.1 -C.sub.4) alkylamino; R.sub.2 represents a halogen atom, a linear alkyl comprising from 1 to 5 carbon atoms which is unsubstituted or substituted with a group chosen from a chlorine atom, a hydroxyl, an amino, a mono (C.sub.1 -C.sub.4) alkylamino or a di(C.sub.1 -C.sub.4) alkylamino; a (C.sub.3 -C.sub.7) cycloalkylamino, or R.sub.2 represents a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridyl-methyl, a 1-pyridyl-1-hydroxymethyl, an imidazolyl-methyl or a 4-thiomorpholinyl, of one of its pharmaceutically acceptable salts or of one of its hydrates.
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