Spray drying process and compositions of fenofibrate
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United States of America Patent
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Feb 24, 2004
Grant Date -
May 16, 2002
app pub date -
Apr 20, 2001
filing date -
Sep 20, 2000
priority date (Note) -
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Abstract
The present invention relates to a novel spray drying process for the preparation of pharmaceutical compositions containing small particles of phospholipid-stabilized fenofibrate. This invention also relates to spray dried powdered compositions prepared according to this process, and to dosage forms of fenofibrate (capsules, tablets, powders, granules, and dispersions) prepared from these powdered compositions. The powdered compositions and dosage forms are useful in the treatment of dyslipidemia and dyslipoproteinemia and have the advantage that they provide reduced in vivo variability in the bioavailability of fenofibrate active species among fed and fasted patients when administered orally.
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