Soft shell gelatin capsules containing non-steroidal anti-inflammatories
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United States of America Patent
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Feb 10, 2004
Grant Date -
Nov 27, 2003
app pub date -
May 15, 2002
filing date -
May 15, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides a pharmaceutical formulation suitable for filling softgel capsules comprising: (a) a therapeutically effective amount of a non-steroidal anti-inflammatory drug selected from the group consisting of selected from the group consisting of (1) the propionic acid derivatives; (2) the acetic acid derivatives; (3) the fenamic acid derivatives; (4) the biphenylcarboxylic acid derivatives; and (5) the oxicams; as well as Cox 2 inhibitors and mixtures thereof; and (b) a solvent system comprising 40% to 60% by weight a polyoxyethylene ether of the formula: ##STR1## wherein n=1 to 6; 15% to 35% by weight of glycerin and 15% to 35% by weight water. In the case of compositions containing an NSAID having carboxyl function an alkaline hydroxide may be added to neutralize said hydroxide function.
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