Preparation of (R -2-alkyl-3-phenylpropionic acids
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United States of America Patent
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Jan 27, 2004
Grant Date -
Jul 24, 2003
app pub date -
Jan 2, 2003
filing date -
Jul 3, 2000
priority date (Note) -
Expired
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Abstract
Compounds of formula (I), wherein R.sub.1 and R.sub.2 are, independently of one another, H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 halogenalkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxy-C.sub.1 -C.sub.6 alkyl, or C.sub.1 -C.sub.6 alkoxy-C.sub.1 l-C.sub.6 alkyloxy, and R.sub.3 is C.sub.1 -C.sub.6 alkyl, are obtainable in high yields by stereoselective addition of R.sub.3 -substituted propionic acid esters to R.sub.1 - and R.sub.2 -substituted benzaldehydes of formula R--CHO to form corresponding 3-R-3-hydroxy-2-R.sub.3 -propionic acid esters, conversion of the OH group to a leavaing group, subsequent regioselective elimination to form 3-R-2-R.sub.3 -propenic acid esters, and their hydrolysis to form corresponding propenic carboxylic acids and their enantioselective hydrogenation, wherein R is (a). ##STR1##
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