Bioactive tetracyclic diterpene compounds and methods of preparation and use thereof
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United States of America Patent
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Jan 27, 2004
Grant Date -
May 8, 2003
app pub date -
Oct 31, 2001
filing date -
Oct 31, 2001
priority date (Note) -
Expired
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Abstract
Newly-isolated and purified metabolites which are effective in regulating the development of at least one filamentous fungal microorganism species are disclosed. These compounds, which are referred to as conidiogenol and conidiogenone, may be used to induce conidiation in and/or to inhibit the growth of populations of such fungal species. The compounds are preferably produced by culture of the fungal species Penicillium cyclopium, and may be subsequently recovered from the culture medium and purified. Methods of using and methods of producing these compounds are also disclosed.
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