Human monoclonal antibodies to CTLA-4

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United States of America Patent

PATENT NO 6682736
SERIAL NO

09472087

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

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Patent Owner(s)

Patent OwnerAddress
AMGEN FREMONT INC6701 KAISER DRIVE FREMONT CA 94555

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Corvalan, Jose Ramon Foster City, CA 14 416
Davis, C Geoffrey Burlingame, CA 25 835
Gilman, Steven Christopher Old Lyme, CT 9 403
Hanke, Jeffrey Herbert Reading, MA 9 403
Hanson, Douglas Charles Niantic, CT 9 403
Mueller, Eileen Elliott Old Lyme, CT 12 603
Neveu, Mark Joseph Mystic, CT 9 403

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