Oil-in-water emulsion for protecting human organs against peroxidation
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United States of America Patent
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Jan 13, 2004
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N/A
app pub date -
Oct 1, 2001
filing date -
Dec 21, 1998
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Abstract
The invention relates to an oil-in-water emulsion comprising, as an active ingredient, .alpha.-tocopherol or the stereoisomers thereof and comprising, as an emulsifier, phospholipids. The inventive emulsion is used in order to attain a protective action against damages to human organs resulting from peroxidation. The emulsion contains a .alpha.-tocopherol content, with regard to action, of 1.48 g/l to 30 g/l RRR-g(a)-tocopherol, 0-25 g/l of an oil which is compatible with I.V. administration, and 0.25 g/l to 3 g/l of a phospholipid. The emulsion is preferably administered as an infusion and is especially used to reduce damages resulting from peroxidation due to ischemia and /or reperfusion and, among other things, during an organ transplantation.
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