Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues

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United States of America Patent

PATENT NO 6673779
APP PUB NO 20030036527A1
SERIAL NO

10163804

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Abstract

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The present invention is directed to a method of stimulating ciliary beat frequency to promote mucociliary or cough clearance of retained mucus secretions from the lungs, sinuses, upper airways, ears, eyes, genito-urinary tract, spermatozoa, ovaries, fallopian tubes, neutrophils, and macrophages of a patient. The method comprises administering uridine triphosphates, adenosine triphosphates, cytidine triphosphates, or dinucleoside tetraphosphates and the derivatives thereof to an affected body of a patient, to treat dysfunction of the mucociliary clearance system as a result of impaired ciliary movement in the patient.

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Patent Owner(s)

Patent OwnerAddress
NORTH CAROLINA AT CHAPEL HILL UNIVERSITY OF308 BYNUM HALL CAMPUS BOX 4105 CHAPEL HILL NC 27599

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boucher, Jr Richard C Chapel Hill, NC 27 1017
Drutz, David J Chapel Hill, NC 10 108
Geary, Cara Cincinnati, OH 1 8
Jacobus, Karla M Cary, NC 14 228
James, Michael K Raleigh, NC 10 174
Lazarowski, Eduardo R Durham, NC 5 161
Pendergast, William Durham, NC 54 857
Rideout, Janet L Raleigh, NC 55 951
Stutts, Monroe Jackson Chapel Hill, NC 8 255
Yerxa, Benjamin R Raleigh, NC 58 936

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